3500Ch26 - Fatty Acid Degradation Three stages Mobilization...

Info iconThis preview shows pages 1–10. Sign up to view the full content.

View Full Document Right Arrow Icon
Fatty Acid Degradation Three stages Mobilization Release to energy requiring tissues Activation of the FA and transport to the mitochondria Breakdown into acetyl- CoA
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Mobilization requires lipases:
Background image of page 2
Lipases are stimulated by hormones
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Glycerol is taken up by the liver and serves as a glycolytic/gluconeogenic precursor
Background image of page 4
Linked to serum albumin
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Fatty acids are linked to Coenzyme A before oxidation FAs need to be activated before they are transported into the mitochondria. This requires ATP and acyl CoA synthetase Occurs at the outer mitochondrial membrane Is a two step process FA reacts with ATP forming acyl adenylate and PPi The SH group of CoA then attacks the acyl adenylate, forming acyl CoA and AMP The partial reactions are freely reversible – so the
Background image of page 6
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Acyl CoA synthetase
Background image of page 8
mitochondria requires Carnitine Acyl CoA molecules are conjugated to carnitine – a zwitterionic alcohol. The acyl carnitine is shuttled across the
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 10
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 02/03/2011 for the course CHEM 3500 taught by Professor Staff during the Spring '08 term at Kennesaw.

Page1 / 33

3500Ch26 - Fatty Acid Degradation Three stages Mobilization...

This preview shows document pages 1 - 10. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online