MMI677_VaccineControversies-20100323

MMI677_VaccineControversies-20100323 - Vaccine...

Info iconThis preview shows pages 1–15. Sign up to view the full content.

View Full Document Right Arrow Icon
Vaccine Controversies 23 March 2010 University of Wisconsin School of Medicine and Public Health
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Synopsis Background on vaccines U.S. Smallpox program - 2002 Cost Effectiveness Thimerosal – Neurodevelopmental issues MMR – Autism Fetal Tissue
Background image of page 2
Vaccine Controversies Background on Vaccines US Birth Cohort ~ 4,000,000 children / year General vaccine coverage ~ 90% doses per vaccine per year = 3,600,000 Financial Implications: $10 vaccine with universal recommendation $36,000,000 per year $108 vaccine with 4 dose $1,555,200,000 per year Global total profit from vaccines Less than profit from a single cholesterol drug
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
0 5 10 15 20 25 30 35 40 45 50 55 Birth 2-M 4-M 6-M 12-M 18-M 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 Age Cumulative Number HPV Tdap Meningococcal Influenza Hep A Pneumococcal Varicella MMR Rota IPV Hib DTaP Hep B Number of Immunizations from Birth to Age 18
Background image of page 4
0 250 500 750 1000 1250 1500 1750 2000 Birth 2-M 4-M 6-M 12-M 18-M 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 Age Cummunlative Cost (US$) HPV Tdap Meningococcal Influenza Hep A Pneumococcal Varicella MMR Rota IPV Hib DTaP Hep B $541 Cost of Immunizations from Birth to Age 18 $223 $1060
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Prevalence, Mortality and Cost recommended childhood and adolescent vaccines 0.001 0.01 0.1 1 10 100 1000 0.1 1 10 100 1000 10000 100000 Pre-vaccine Prevalence (cases/100,000) Case Fatality Rate (per 1000 cases) $300 $50 $100
Background image of page 6
Comparative Costs to fully Immunize all  American Children (77.9 million children: ages 0 – 18) 134 713 0 100 200 300 400 500 600 700 800 Billions of Dollars Childhood Immunization Iraq War (as of 3/22/10) Sources of population and cost information: http://www.census.gov; http://www.costofwar.com
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Vaccine Controversies Smallpox (Variola major)
Background image of page 8
Smallpox: Overview 1949 - Last U.S. case 1972 - End of routine childhood vaccination 1980 - Global eradication U.S. and Russia maintain cultures of Variola History of weaponization Efficient person-to-person aerosol/contact transmission Up to 30% mortality CDC: Electron micrograph of Variola major
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Smallpox Vaccine Immunity not life-long old vaccine available Made from live Vaccinia 14 million doses 1:5 dilution = 70 million
Background image of page 10
Eczema vaccinatum. Photo courtesy of John M. Leedom, M.D. Smallpox Vaccine Complications
Background image of page 11

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Rates of Complication from Vaccinia Vaccine 0.4 5.25 1.1 1.5 12.3 38.5 241.5 529.2 0 100 200 300 400 500 600 OPV WCP Death Vaccinia Necrosum Encphalitis Eczema Vaccinatum Generalized Vaccinia Autoinnoculation Events per 1,000,000 doses Lane et al, J Infect Dis 1970: 122:303-9
Background image of page 12
Number of Smallpox citations reported on MEDLINE per month ( January 1999 -February 2004 ) 0 10 20 30 40 50 60 70 80 No. MEDLINE citations | 1999 | 2000 | 2001 | 2002 | 2003 | September 11th, 2001 Anthrax Attacks Start of Iraq war “End of hostilities” Start of civilian vaccination
Background image of page 13

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Smallpox Questions Was a vaccine program used politically to
Background image of page 14
Image of page 15
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 02/04/2011 for the course BIOL 4486 taught by Professor Staff during the Fall '08 term at Kennesaw.

Page1 / 63

MMI677_VaccineControversies-20100323 - Vaccine...

This preview shows document pages 1 - 15. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online