Overheads - revised (Dr. Burnham)

Overheads - revised (Dr. Burnham) - BIO 200 LECTURE 1...

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BIO 200 LECTURE 1 INTRODUCTION I: ORIENTATION & DEFINITIONS I. BASIC DEFINITIONS: WHAT IS PHARMACOLOGY? WHAT IS A DRUG? 1. PHARMACOLOGY IS: Broad Definition Narrow Definition “the science of pharmacological agents” “the science of drugs” 2. A DRUG IS : “a chemical substance, not part of the normal diet, which affects an organism’s physiology.” Broad Definition Narrow Definition “any effect” (“drugs” + “poisons”) “Pharmacon / Xenobiotic” “desired effect” (only “drugs”) “medicine”/ “recreational drug”
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DISCUSSION POINTS RELATED TO DEFINITIONS QUERY : Drugs vs. foods? Drugs vs. medicines? Drugs vs. poisons? Disinfectants? NOTE : In general, “medicines” normalize physiology, but any drug in excess = a “poison”. NOTE : Drugs are: 1) often organic compounds 2) often have a MW around 300 3) often affect excitable membranes (chemical messenger systems, ion channels) 4) usually act by binding to proteins
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II. SUB-FIELDS OF PHARMACOLOGY 1. PHARMACOKINETICS ABSORPTION DISTRIBUTION BIOTRANSFORMATION ELIMINATION 2. PHARMACODYNAMICS MECHANISM OF ACTION
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III. RELATED DISCIPLINES 1. ACADEMIC BIOCHEMISTRY PHYSIOLOGY 2. REAL WORLD PHARMACOTHERAPEUTICS (THERAPEUTICS) TOXICOLOGY PHARMACY PHARMACEUTICAL CHEMISTRY PHARMACOECONOMICS
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IV. REFERENCES / SOURCES OF INFORMATION 1. THE PHARMACOLOGICAL BASIS OF THERAPEUTICS 11 th ed , Hardman et al. (eds.) (2005): An excellent handbook, widely used by pharmacologists and doctors. (Generally called “Goodman and Gilman” after the original editors.) 2. COMPENDIUM OF PHARMACEUTICALS AND SPECIALTIES : Issued annually, this Canadian book is a compendium of product information supplied by the manufacturers. It also contains lists of manufacturers, addresses, etc. (Called the “CPS”.) 3. PHYSICIANS’ DESK REFERENCE: The American version of the CPS. (Called the “PDR”.) 4. THE MERCK INDEX: A handbook which describes the physical properties of many chemicals, including drugs. The place to go for information on molecular weight, melting point, etc. IV. READINGS IN THE COURSE Readings are in Principles of Medical Pharmacology (7 th Ed.), edited by Kalant et al. Chapters for reading are indicated on the lecture schedule. In general, understand what the tables and figures in the text are trying to say, but don’t memorize material in them unless I say so. Do learn the material in table 1-1.
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BIO200 LECTURE 2 INTRODUCTION II: WHERE DO DRUGS COME FROM? / DRUG NAMES I. SOURCES OF DRUGS 1. NATURAL SOURCES (TRADITIONAL SOURCE) 1. PLANTS (Most Important) Alkaloids (the majority of drugs) Nonalkaloids 2. ANIMALS Venoms Hormones 3. MINERALS 4. MICRO-ORGANISMS 2. CHEMICAL SYNTHESIS (no molecule in nature)
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Learn this table: Source: Principles of Medical Pharmacology ; Kalant, Grant, and Mitchell (Ed.s), Toronto: Elsevier, 2007, pp. 6.
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II. DRUG CLASSSIFICATION ACCORDING TO SOURCE : 1. CRUDE NATURAL PREPARATIONS (“galenicals”) opium 2. PURE EXTRACT FROM NATURAL PREPARATIONS morphine 3. SEMI-SYNTHETIC heroin 4. PURE SYNTHETIC meperidine
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III. MODERN DRUG DEVELOPMENT A: DRUG SYNTHESIS/DISCOVERY 1. Purification from natural sources 2.
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This note was uploaded on 01/30/2011 for the course BIO 200 taught by Professor B during the Fall '10 term at University of Toronto- Toronto.

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Overheads - revised (Dr. Burnham) - BIO 200 LECTURE 1...

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