Test 2 - 2009 without answers

Test 2 - 2009 without answers - BIO 200 FACULTY OF ARTS...

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BIO 200 Term Test #2 (correct answers) October 29, 2009, 5:15 – 6:45 pm Room SE 2082 and CC 1140 Value: 30 % of FINAL MARK _______________________________________________________________________ _ DO NOT OPEN THIS BOOKLET UNTIL INSTRUCTED TO DO SO . 1. STUDENT NAME, NUMBER AND SIGNATURE should be entered on the scantron answer sheet. Please enter your student number carefully. 2. All questions are of the "multiple choice" type. There is only one correct answer to each question. If two options seem possible, choose the better of the two. 3. All answers must be entered on the scantron answer sheet in black pencil. Ask for a pencil if you don’t have one. 4. Non-programmable calculators may be used. (Programmable calculators will be erased at the start of the exam.) 5. You have 1.5 hours for the exam. There are 45 items. 6. Abbreviations : ASA = acetylsalicylic acid; Cl H = hepatic clearance; SA = salicylic acid; P o/w = partition coefficient; Vd = apparent volume of distribution. 7. If there is a range, use the highest figure for the pharmacokinetic indices. 8. Remember: log 1 = 0, log 10 = 1, log 100 = 2, log 1000 = 3. 9. You may keep the exam booklet at the end of the exam. Correct answers will be posted on the website. Good Luck
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Renal and Hepatic Elimination / Clearance 1. True statement: a) Drugs with a short half-life cannot have a long duration of therapeutic action. b) Drugs with a high partition coefficient cannot be eliminated by the kidneys; they must be biotransformed and excreted as metabolites. c) Total body clearance = hepatic clearance multiplied by renal clearance. d) k = the absolute amount of drug (in mg) eliminated per unit time. e) “Pseudo zero order” metabolism is seen with digoxin and neostigmine; it occurs after the saturation of tubular secretion. . 2. All of the following statements about glomerular filtration are true, EXCEPT : a) It occurs at a rate of 120 ml/minute. b) It is a “passive” process that doesn’t require the expenditure of energy. c) It can be measured using inulin or creatinine. d) It eliminates polar molecules in unchanged form. e) It eliminates molecules that are bound to plasma proteins. 3. True statement about tubular reabsorption: a) It follows the molecule’s concentration gradient. b) It requires an expenditure of energy (with high Po/w molecules). . c) It can increase renal clearance up to a rate of 600 ml/min. d) Plasma protein binding in the renal tubules increases the rate of tubular reabsorption. e) It only occurs with drugs that have a low partition coefficient. 4. True statement about tubular secretion: a) Administration of probenecid increases the tubular secretion of penicillin. b)
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This note was uploaded on 01/30/2011 for the course BIO 200 taught by Professor B during the Fall '10 term at University of Toronto.

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Test 2 - 2009 without answers - BIO 200 FACULTY OF ARTS...

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