10-12-10 Lecture 6

10-12-10 Lecture 6 - Import of proteins into mitochondria...

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Figure 12-21a Molecular Biology of the Cell (© Garland Science 2008) Import of proteins into mitochondria cristae
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Figure 12-22 Molecular Biology of the Cell (© Garland Science 2008) Signal sequence Import Receptor Amphiphilic alpha helix Signal sequence of mitochondrial Cytochrome Oxidase +vely charged residues (red) Hydrophobic residues (yellow)
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Figure 12-23 Molecular Biology of the Cell (© Garland Science 2008) Protein translocators in the mitochondrial membranes
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Figure 12-25 Molecular Biology of the Cell (© Garland Science 2008) Protein import by mitochondria Cytosolic Hsp70
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Figure 12-26 Molecular Biology of the Cell (© Garland Science 2008) mtHSP60 Role of chaperones, energy, and membrane potential in protein import into the mitochondrial matrix space
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Figure 6-86 Molecular Biology of the Cell (© Garland Science 2008) Hsp70 family members and other interacting proteins keep the proteins for mitochondrial import unfolded
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Figure 6-87 Molecular Biology of the Cell (© Garland Science 2008) HSP60
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Midterm Exam I October 14 – Thursday – 9-10.20 AM Lectures covered 1-6 Bring – Scantron sheet and #2 Pencils
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Methods For Studying – Protein Import
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10-12-10 Lecture 6 - Import of proteins into mitochondria...

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