11-2-10 Lecture 11

11-2-10 Lecture 11 - Signaling through enzyme-coupled...

Info iconThis preview shows pages 1–4. Sign up to view the full content.

View Full Document Right Arrow Icon
Figure 15-16c Molecular Biology of the Cell (© Garland Science 2008) Catalytic domain may be part of receptor cytoplasmic domain or part of an associated protein. Signaling through enzyme-coupled receptors
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Peyton Rous – proposed viruses can cause cancer Plymouth rock hen 1911: Rous attempted to transfer chicken's tumors. When he injected small pieces of the growth into hens from the same bloodline they too developed tumors. Rous later found that tumor formation did not require transfer of intact tumor cells, and could be achieved using cell-free filtrates. He thus concluded that the tumors were caused by a “filterable agent”, as viruses were then known. Rous sarcoma virus (RSV) The Nobel Prize in Physiology or Medicine 1966 Receptor tyrosine kinases Src is the founding member of family of tyrosine kinases
Background image of page 2
Src kinase The v-src gene is responsible for the tumor causing potential of the virus and was the ±rst of many tumor-causing genes, or oncogenes, to be isolated from viruses.
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 4
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 01/31/2011 for the course BIS 104 taught by Professor Scholey during the Spring '08 term at UC Davis.

Page1 / 22

11-2-10 Lecture 11 - Signaling through enzyme-coupled...

This preview shows document pages 1 - 4. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online