11-16-10 Lecture 13

11-16-10 Lecture 13 - Actin binding proteins determine the...

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Actin binding proteins determine the rate of assembly and disassembly as well as the availability of G-actin for polymerization.
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Capping proteins block assembly and disassembly at filament ends
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Actin nucleation by the formin FH2 domain
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Regulation of formins
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Actin nucleation by the Arp2/3 complex WASP = Wiskott-Aldrich syndrome protein
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Regulation of Arp2/3 complex by WASP
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Shigella Cause bacillary dysentery or shigellosis The source in each case is unwashed hands Human is the only “reservoir” Uses power of actin polymerization for intracellular movement Microbiol. Mol. Biol. Rev. 65:595-626
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N-WASP activation Actin nucleation Actin-based motility Microbes and Infection 2:813-819 Shigella uses power of actin polymerization for intracellular movement
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Listeria uses power of actin polymerization for intracellular movement ATP-G-actin, Arp2/3 complex, CapZ, and Cofilin Listeria - Intracellular bacteria Food borne pathogen causes mild gastrointestinal symptoms in most adults Can be fatal in elderly that are immunocompromised
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• Is an extracellular pathogen • EPEC is a serious and widespread cause of infantile diarrhea • 2 million deaths/year; particularly infants younger than 5 years
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This note was uploaded on 01/31/2011 for the course BIS 104 taught by Professor Scholey during the Spring '08 term at UC Davis.

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11-16-10 Lecture 13 - Actin binding proteins determine the...

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