11-23-10 Lecture 15

11-23-10 Lecture 15 - Intermediate filaments (IFs) IFs diff...

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Intermediate filaments (IFs) IFs diff from actin and MTs: - Biochemically they are much more heterogeneous and often expressed in a tissue-dependent manner - They have great tensile strength hair and nail consists primarily of the IFs of dead cells. - They do not have an intrinsic polarity and their constituent subunits do not bind nucleotide - No known motors associated with IFs - More stable than actin and MTs - Only found in metazoans; not in fungi and plants
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Structure and assembly of intermediate filaments
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Intermediate filaments are dynamic
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Transgenic mice carrying a mutant keratin gene exhibit blistering similar to that in the human disease Epidermolysis bullosa simplex (EBS)
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REGULATION OF CELL CYCLE Figure 17-2 Molecular Biology of the Cell (© Garland Science 2008)
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A diffusible factor in mitotic cells induces mitosis in interphase cells S phase G2 phase
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factor -- cyclin
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This note was uploaded on 01/31/2011 for the course BIS 104 taught by Professor Scholey during the Spring '08 term at UC Davis.

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11-23-10 Lecture 15 - Intermediate filaments (IFs) IFs diff...

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