0-Discussion 2

0-Discussion 2 - BCH 100 Discussion 2 1/19/10 Table3.2pK...

Info iconThis preview shows pages 1–7. Sign up to view the full content.

View Full Document Right Arrow Icon
BCH 100 Discussion 2 1/19/10
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Isoelectric pH (pI) α- NH 3 + α- COOH 6.02 5.41 5.65 5.97 6.02 6.02 5.74 5.48 6.30 5.68 6.53 5.89 5.97 pK a  of pK a  of pK a  of pI ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- valine 2.32 9.62 tryptophan 2.38 9.39 10.43 2.63 threonine serine 2.21 9.15 10.60 1.99 proline phenylalanine 1.83 9.13 9.21 2.28 methionine 9.68 2.36 leucine isoleucine 2.36 9.68 glycine 2.34 9.60 9.13 2.17 glutamine 8.80 2.02 asparagine 9.69 2.34 alanine Side Chain polar side chains Table 3.2 pK a  and pI of  α -amino acids
Background image of page 2
Levels of Protein Structure Levels of Protein Structure Nelson & Cox, Lehninger Principles of Biochemistry, 4th ed., Fig. 3-16
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Protein Protein Function Function : : Myoglobin (Mb) primary function is binding/releasing O 2 in cells, esp. muscle: O 2 is the ligand for Mb. Mb was 1st protein 3 o structure determined (X-ray cryst.) single polypeptide chain, 153 amino acids has a single heme group in a hydrophobic pocket 8 α -helices, no β conformation 2 (polar) His residues in the interior -- 1 Mb + O 2 Mb-O 2
Background image of page 4
Mb Mb function function : : heme structure heme structure O 2 binding site His E7 (helps bind O 2 ) His F8 (coordinates heme) HEME Fe(II) of heme has 6 coordination sites; 4 interact with N atoms of heme, 1 with N of a His side chain, and 1 with the O 2 molecule
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Quaternary Structure Quaternary Structure 4° structure: 4° structure: the association of polypeptide monomers into multi- subunit proteins examples we will see in this course Globular Protein Subunits Alcohol dehydrogenase 2 Triosephosphate isomerase 2 Aldolase 3 Lactate dehydrogenase 4 Hemoglobin 2 + 2 Pyruvate kinase 4 Insulin 6
Background image of page 6
Image of page 7
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 01/31/2011 for the course BCH BCH100 taught by Professor Sato/z during the Winter '10 term at UC Riverside.

Page1 / 30

0-Discussion 2 - BCH 100 Discussion 2 1/19/10 Table3.2pK...

This preview shows document pages 1 - 7. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online