Discussion 3 Midterm I Review-rev

Discussion 3 Midterm I Review-rev - BCH 100 Discussion 3...

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BCH 100 Discussion 3 Midterm I Review Midterm: 3:10 - 4:00 PM in LFSC 1500, Wed, 1/27 MUST : A half-sheet scantron (form #882-E, bookstore) A non-graphing calculator to the exam. NO C ell phones anywhere; OFF Sit in every other seat except every seat in first 4 rows Name on every page, name and EXAM FORM (A/B) on scantron. When you finish, place scantron inside exam itself and turn it in.
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MIDTERM I: 100 pts Dr. Ziegler’s Lectures #2 - #9 Water, Acids, Bases, Buffers Amino Acids, Peptides Protein Structure and Function Enzymes (Intro, Kinetics & Inhibition; Lipids and Membranes Carbohydrates
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Lecture 2: Water, Noncovalent Bonds, Acids, Bases, Buffers Solvent Properties of H Solvent Properties of H 2 O: O: Hydrophilic: Hydrophilic: tends to dissolve in H 2 O Amino Acids side chains: polar, charged (+/-) Hydrophobic: Hydrophobic: tends not to dissolve in H 2 O Polar: N,Q,S,T,Y,C + charged: K ( lys ),R,H - charged: D,E Non-polar: G,A,V,L( leu ),I,M,F,W,P Amphipathic (= amphiphilic): Amphipathic (= amphiphilic): both fatty acids and cholesterol are amphipathic longer chains (V,L,I), F M the most hydrophobic
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Hydrogen Bonds Hydrogen bond: directional Hydrogen bond: directional Donor groups N–H -----> O–H -----> Acceptor groups N: <---- O: <---- Hydrogen bond in α -helices and β -pleated sheets: the amide N-H (donor) carbonyl oxygens (acceptor) of peptide backbone α -helix β -sheet “donor” “acceptor”
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Weak Acids and Bases: Weak Acids and Bases: The Henderson-Hasselbalch Equation The Henderson-Hasselbalch Equation HA H 2 O A - H + + Weak acid Conjugate base [Weak acid] [Conjugate base][H + ] K a  =  Dissociation constant: Based on any 2 of 3 factors (pH, pKa and [base]/[acid] ratio ), the other one can be calculated.
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Using Henderson-Hasselbalch Equation: Using Henderson-Hasselbalch Equation: When the concentrations of weak acid and its conjugate base are equal, the pH of the solution equals the pK a of the weak acid. When pH < pK a , the weak acid predominates. When pH > pK a , the conjugate base predominates. [Weak acid] [Conjugate base] log = pH pK a   + For the side chain carboxyl group of glutamic acid with a pKa of 4.0, at different pH values below, is the conjugate acid or base dominant (w/o a calculator)? - pH 4.0? - pH 6.5? - pH 2.6?
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[Weak acid] [Conjugate base] log = pH pK a   + = RATIO of conj. base/acid For the side chain carboxyl group of glutamic acid with a pK a of 4.0, what is the ratio of COO to COOH at pH 4.5? log [COO ] [COOH] = 4.5 – 4.0 = 0.5 [COO ] [COOH] = 10 0.5 = 3.16 1 For the side chain carboxyl group of glutamic acid with a pK a of 4.0, what is the percentage/fraction of the group in the conjugate base form at pH 4.5?
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Discussion 3 Midterm I Review-rev - BCH 100 Discussion 3...

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