CBNS120 discussion 3

CBNS120 discussion 3 - Structure:typeI,II,IIIprotein,

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Structure: type I, II, III protein, 1. a single transmembrane  - α helix  (bitopic) 2. a polytopic  - α helical protein  3. a transmembrane    β barrel  Muscle nicotinic  acetylcholine receptor  (nAChR) fig 3.1 A α  subunit: 
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To estimat Vm and consider multiple ions, use  Goldman equation HW 1: K+: 400mM/10mM;  Na+: 50mM/460mM;  P Na =1/50 P K  ;   13°C HW2: Why is Keq different than Em? HW 3: Cell without sodium  channel? HW 4:  overshoot! What if P ion  (g ion ) all increase at the  same time?
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The membrane potential is always driven toward the equilibrium potential of the ion to which the membrane is most permeable. That is why we have depolarization during action potential! To estimat Vm at a time, consider multiple ions, use  Goldman equation 1. Threshold for massive amount of voltage gated Na+ channel to  open 2. Rising Phase because of Na+ influx (try to bring Vm to its own 
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CBNS120 discussion 3 - Structure:typeI,II,IIIprotein,

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