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HomeworkQuestionsWeek3(11) - Study Questions Week 3 1...

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Study Questions - Week 3 1. Consider a squid axon bathed in seawater under artificial conditions, and the following ion concentrations: [K] i = 400 mM and [K] o = 10 mM, [Na] in = 50 mM, [Na] o = 460 mM. Predict E K and E Na at a temperature of 13 o C. Assuming that the Na permeability of the cell membrane is 1/50 that of the K permeability, predict E m , assuming that Cl is in equilibrium. 2. Why is K eq different than E m ? 3. Adjacent to the neuron is a glial cell, which has no sodium channels in the plasma membrane. Predict its resting potential, using the ion concentrations provided in Problem 1. 4. What was Bernstein’s hypothesis regarding the nerve impulse and what key experimental result disproved it? 5. What happens to the amplitude of the squid axon action potential when [Na] o is reduced? Why? 6. In what sense is the action potential “regenerative”? 7. What is the “early inward current” and the “late outward current” recorded by Hodgkin and Huxley from the squid axon under voltage clamp conditions?
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