Lecture3(11) - From Purves et al., 2004 Neuroscience, pg....

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Lecture 3 - Structure and Properties of Ion Channels
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From Purves et al., 2008 4th Ed., Neuroscience, pg. 67
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Nicotinic Acetylcholine Receptor
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Torpedo californica
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(From Raftery et al. Science , 208: 1454-1457, 1980)
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(From Raftery et al. Science , 208: 1454-1457, 1980)
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From Purves et al., 2004 Neuroscience, pg. 136
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Construction of cDNA Library
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(From Watson et al., Recombinant DNA , 3rd Ed., Cold Spring Harbor Laboratory Press; pg. 95) Use of PCR to Clone Novel, but Related Channels
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Sequence of alpha-subunit of Torpedo nACHR
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Hydropathy Plot of Ligand-gated Receptor Channels
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(From Siegel et al. 1993, Basic Neurochemistry , 5th Ed., Raven Press)
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Early 3-D Model for nACHR Postulated by Numa & Colleagues
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Subsequent Model for nACHR from Unwin et al.
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Heterologous Expression of Channels
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From Hille, B. 2001, Ion Channels of Excitable Membranes, pg. 412
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The Electric Eel is Rich Source of Na Channels http://en.wikipedia.org/wiki/File:Electric- eel2.jpg
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http://en.wikipedia.org/wiki/Puffer_fish Puffer Fish (fugu): Source of Tetrodotoxin, a Selective Na Channel Blocker
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Unformatted text preview: From Purves et al., 2004 Neuroscience, pg. 79 From Purves et al., 2008 4th Ed., Neuroscience, pg. 75 From Catterall (2005) Voltage-gated Sodium Channel From: Nicholls, J. G. et al., (2001) From Neuron to Brain , 4th Ed., Sinauer & Assoc. pg. 107 Voltage-gated Calcium Channel From Catterall et al., (2003) Pharmacol Rev 55: 579 From Olivera et al., 1994 Ann. Rev. Biochem. 63: pg. 833 Toxins Can be Used as Molecular Calipers Bacterial (KcsA) Potassium Channel From Morais-Cabral et al., 2001 Nature 414: 37-42 Out In From Miller, C. 2001 Nature 414: 23-24 Newtons Balls at Burning Man http://www.sattlers.org/mickey/travel/1996/burningMan/21-newtons-balls.html From Morais-Cabral et al., 2001 Nature 414: 37-42 Valinomycin Nonactin From Morais-Cabral et al., 2001 Nature 414: 43-48 Stereo-pairs (From Yu et al., 2005, Pharmacol Rev 57: 387-395) From Purves et al., 2008 4th Ed., Neuroscience, pg. 71 From Gutman et al. Pharmacol Rev (2005) 55: 583 From Purves et al., 2008 4th Ed., Neuroscience, pg. 75...
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Lecture3(11) - From Purves et al., 2004 Neuroscience, pg....

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