Lecture4(11) - Relative [Ca]in [Ca]out Na-Ca exchange can...

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Transport Across Cell Membranes Lecture 4
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From: Purves et al. (2008) Neuroscience , pg. 78
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First Evidence for Na/K ATPase Discovered in Squid Axon From: Purves et al. (2008) Neuroscience , pg. 79
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From: Purves et al. (2008) Neuroscience , pg. 81 Models for ATPase Structure/Function Digitalis purpurea (Foxglove)
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Na/K pump is electrogenic pump
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Signaling Function for Na/K ATPase From: Purves et al. (2008) Neuroscience , pg. 80
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In Vivo: Neocortical Seizures Hyperpolarization
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Extracellular K+ concentration is reduced below baseline and cell is hyperpolarized after seizure Model Model Model Experiment Hyperpolarization
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Na-Ca Exchanger
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Na-Ca Exchanger: Response to Changes in Extracellular Ions
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Unformatted text preview: Relative [Ca]in [Ca]out Na-Ca exchange can reverse for more positive Vm 3( ); 2( ) 3( ) 2( ); (3 2 ) (3 2 ) Na Na m Ca Ca m Na Ca Na m Ca m m Na Ca m Na Ca W E V W E V W W normal pump operation E V E V V E E normal pump operation if however V E E reversal pump operation =-=----<----Chloride-Bicarbonate Exchanger Potassium-Chloride Cotransporter Chloride Transporters From Ben-Ari (2002) Nat. Rev. Neurosci. 3(9):728-39 Relative Expression of Chloride Transporter Genes Determines Excitatory vs. Inhibitory Actions of GABA Vesicular Transporters Neurotransmitter Transporters...
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Lecture4(11) - Relative [Ca]in [Ca]out Na-Ca exchange can...

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