Lecture6-7(11)

Lecture6-7(11) - Resting potential Na Na K K Cl Cl rest Na K Cl g E g E g E V g g g = Sum of all ionic current equals to zero Na Na K K Cl Cl g V E

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Unformatted text preview: Resting potential Na Na K K Cl Cl rest Na K Cl g E g E g E V g g g + + = + + Sum of all ionic current equals to zero: ( ) ( ) ( ) Na Na K K Cl Cl g V E g V E g V E- +- +- = , K Na Cl If g g g 58log([ ] / [ ] ) rest K out in V E K K ≈ = [ ] [ ] [ ] 58log [ ] [ ] [ ] Na o K o Cl i rest Na i K i Cl o P Na P K P Cl V P Na P K P Cl + + = + + Ionic Basis of the Nerve Impulse Lectures 6 & 7 From “Dynamical systems in neuroscience” by E.Izhikevich From Purves et al., Neuroscience Positive feedback Negative feedback Increasing the amplitude of the external stimulation transforms subthreshold (no AP) response to AP generation. Subthreshold stimulus – no positive feedback => no AP Superthreshold stimulus – positive feedback => AP Positive feedback V c I FB (Subtract late current from total current) I Na I K Peak of g K and g Na as a function of membrane voltage , , , , / ( ) / ( ) K peak K peak m K Na peak Na peak m Na g I V E g I V E =- =- I K I Na / ( ) / ( ) K K m K Na Na m Na g I V E g I V E =- =- Time course of g K and g Na ( , ) Na g F V t = ( , ) K g F V t = g K and g Na depend on the membrane voltage and time Potassium current...
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This note was uploaded on 01/31/2011 for the course CBNS 120 taught by Professor Adams during the Winter '10 term at UC Riverside.

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Lecture6-7(11) - Resting potential Na Na K K Cl Cl rest Na K Cl g E g E g E V g g g = Sum of all ionic current equals to zero Na Na K K Cl Cl g V E

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