Adipose2010

Adipose2010 - The Adipocyte: More Than Just Fat Just 1...

Info iconThis preview shows pages 1–23. Sign up to view the full content.

View Full Document Right Arrow Icon
The Adipocyte: More Than The Adipocyte: More Than Just Fat Just Fat
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Types of Adipose Tissue Brown Adipose Tissue (BAT) Heat production White Adipose Tissue (WAT) Develops after birth Subcutaneous and visceral Energy Storage 1
Background image of page 2
Obesity Obesity Excess Fat Excess Fat Hypertrophy Hyperplasia Fat cell size Cell number 4
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Brown adipocyte morphology Sell, Int J Biochem and Cell Biol, 2004
Background image of page 4
UCP1 Intermembrane space Matrix Inner mitochondria membrane Electron Transport chain H+ H+ H+ H+ H+ H+ H+ ADP + Pi ATP ATP synthase ATP Synthesis Hydrogen ions are pumped into the intermembrane space H+ is pumped back into the matrix as the dissipation of the H+ gradient is coupled to ATP production Coupling of fuel oxidation and ATP synthesis
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
UCP1 Intermembrane space Matrix Inner mitochondria membrane Electron Transport chain H+ H+ H+ H+ H+ H+ H+ ADP + Pi ATP ATP synthase Uncoupling of fuel oxidation and ATP synthesis UCP1 H+ H+ Heat UCP1 uses the H+ gradient to generate heat As a result, less ATP is made for every unit of fuel oxidized From FA or glucose oxidation
Background image of page 6
Unexpected evidence for active brown adipose tissue in adult humans Nedergaard et al Am J Physiol Endocrinol Metab 293: E444–E452, 2007.
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
2-[18F]fluoro-2-desoxy-glucose (FDG) uptake in brown fat cells.
Background image of page 8
Identification and Importance of Brown Adipose Tissue in Adult Humans Cypess et al N Engl J Med 2009;360:1509-17.
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Outdoor temp and BAT
Background image of page 10
BAT age BMI
Background image of page 11

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Cold-Activated Brown Adipose Tissue in Healthy Men van Marken Lichtenbelt et al N Engl J Med 2009;360:1500-8.
Background image of page 12
Activity and Volume of Brown Adipose Tissue, Resting Metabolic Rate Adjusted for Fat-free Mass and Body Temperature under Thermoneutral Conditions (22°C) and after 2 Hours of Cold Exposure (16°C).
Background image of page 13

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
BAT BMI
Background image of page 14
Energy Expenditure BMI
Background image of page 15

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Functional Brown Adipose Tissue in Healthy Adults Virtanen et al N Engl J Med 2009;360:1518-25.
Background image of page 16
Cold induction BAT
Background image of page 17

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Cold warm glucose
Background image of page 18
UCP1 is BAT specific
Background image of page 19

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Adipocytes regulate energy balance by endocrine and non endocrine mechanisms.
Background image of page 20
Does removing fat reduce fat? Brain–adipose tissue cross talk, Bartness et al Proceedings of the Nutrition Society (2005), 64, 53–64.
Background image of page 21

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Siberian hamsters When housed in long ‘summer-like’ days Siberian hamsters show a marked seasonal obesity (40–50% body fat) that gradually and naturally develops across the first 1–2 months of life. Most remarkably, this obesity is
Background image of page 22
Image of page 23
This is the end of the preview. Sign up to access the rest of the document.

This document was uploaded on 01/31/2011.

Page1 / 57

Adipose2010 - The Adipocyte: More Than Just Fat Just 1...

This preview shows document pages 1 - 23. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online