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FatCallTurnover2010

FatCallTurnover2010 - after bomb tests Adipocyte death...

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Dynamics of fat cell turnover in humans Spalding et al NATURE Vol 453|5 June 2008
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Methods To establish the dynamics within the stable population of adipocytes in adults, we have measured adipocyte turnover by analyzing the integration of 14C derived from nuclear bomb tests in genomic DNA. Approximately 10% of fat cells are renewed annually at all adult ages and levels of body mass index. Neither adipocyte death nor generation rate is altered in early onset obesity, suggesting a tight regulation of fat cell number in this condition during adulthood.
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Fat mass determined by volume and size
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Adipocyte number stability Adipocyte number increases in childhood and adolescence, with the number leveling off and remaining constant in adulthood in both lean (blue) and obese (pink) individuals.
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14C from atomic bomb tests
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14C in people born before atomic tests
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14C in adipose DNA for people born after bomb tests
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Unformatted text preview: after bomb tests Adipocyte death fraction Adipocyte production rates Adipocyte age Bariatric surgery and fat cell number or volume Major weight loss by bariatric surgery results in a significant decrease in cell volume, however it fails to reduce adipocyte cell number, 1-2 yr post surgery (n=20). All error bars represent s.e.m.; asterisk, P,0.0001. Fat cell turnover in humans Peter Arner and Kirsty L. Spalding Biochemical and Biophysical Research Communications 396 (2010) 101Ð104 Cellularit y lean vs obese Fat dynamics The rate of cell turnover (i.e. the proportion of adipocytes turning over relative to the total number of adipocytes) is the same for both groups. The high turnover of adipocytes establishes a new therapeutic target for pharmacological intervention in obesity, where a change in the fat mass may be achieved by increasing adipocyte death (+)...
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