MC4RMendelianObesity2010

MC4RMendelianObesity2010 - Mechanisms for melanocortin 4...

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Mechanisms for melanocortin 4 receptor (MC4R) mutations to cause human obesity
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Gut peptides and the brain
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POMC processing
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Obese Red Head with POMC mutation
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Weight gain POMC mutation
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POMC mutation
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POMC processing mutant
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Ligand Selectivity and Tissue Distribution of the 5 known Melanocortin Receptor Subtypes
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Hormone levels in POMC kids
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Specific POMC mutation
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Effect of mutations on POMC
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Humans with MC4R mutations Sequencing has revealed that between 1-5% of children with BMI>40 have mutations in MC4R. This suggests that there may be tens of thousands of people with obesity due to MC4R mutations, since there are millions of people in the USA with BMI>40. This raises many questions -- how to cure people with this form of obesity? What is the true prevalence of obesity due to MC4R?
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MC4R heterozygous families
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MC4R homozygous families
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Boy with MC4R
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Girl with MC4R
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Correlation of body fat and leptin in controls and carriers of MC4R or leptin mutations.
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MC4R mutations Farooqi
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Types of MC4R mutations
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MC4R mutations and signaling activity
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Homozygous and heterozygous mutations MC4R
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Height and MC4R
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0 50 100 150 200
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MC4RMendelianObesity2010 - Mechanisms for melanocortin 4...

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