MendelianObesity2010

MendelianObesity2010 - Me nd e lia no b e s ity Exa m p le...

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Me nde lia n o b e s ity Exa m ple s  a nd illus tra tio ns  o f  b a s ic  princ ipa ls  o f we ig ht  re g ula tio n pro vide d b y s tudie s   o f pe o ple  with Me nde lia n 
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Mendelian Disease Essentially…If you inherit the  mutation, you have the disease.  R r R r RR Rr Rr rr Complex Disease Essentially…genotype  doesn’t always predict  phenotype due to complexities R r R r RR Rr Rr rr? affected Dependent on gene interactions,  environment, etc. 
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Obesity is a Complex Disease OBESITY Genetics How many? What impact? How many people have the mutation? Environment How to measure? How to control for? How does gene interact with environment Different for every gene?
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What accounts for the genetic determinants of  common   obesity? Multiple genes, gene-gene interactions, gene-environment interactions Common disease/Common variant theory  c o m m o n va ria nts  tha t c o nfe r o nly inc re a s e d ris k fo r  the  individua l, b ut pro po rtio n o f po pula tio n it wo uld  a ffe c t wo uld b e  hig h.  Rare Variant theory ra re  m o no g e nic  va ria nts  -- m a ny in a  po pula tio n. 
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MendelianObesity2010 - Me nd e lia no b e s ity Exa m p le...

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