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MendelianObesity2010

MendelianObesity2010 - Me nd e lia no b e s ity Exa m p le...

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Me nde lian o be s ity Exam ple s  and illus tratio ns  o f  bas ic  princ ipals  o f we ig ht  re g ulatio n pro vide d by s tudie s   o f pe o ple  with Me nde lian  fo rm s   o f o be s ity. 
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Mendelian Disease Essentially…If you inherit the  mutation, you have the disease.  R r R r RR Rr Rr rr Complex Disease Essentially…genotype  doesn’t always predict  phenotype due to complexities R r R r RR Rr Rr rr? affected Dependent on gene interactions,  environment, etc. 
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Obesity is a Complex Disease OBESITY Genetics How many? What impact? How many people have the mutation? Environment How to measure? How to control for? How does gene interact with environment Different for every gene?
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What accounts for the genetic determinants of  common   obesity? Multiple genes, gene-gene interactions, gene-environment interactions Common disease/Common variant theory  c o m m o n variants  that c o nfe r o nly inc re as e d ris k fo r  the  individual, but pro po rtio n o f po pulatio n it wo uld  affe c t wo uld be  hig h.  Rare Variant theory rare  m o no g e nic  variants  -- m any in a po pulatio n. 
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