Genetics problem set

Genetics problem set - Lecture 4: Chromosomal Basis of...

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Lecture 4: Chromosomal Basis of Inheritance General Concepts To Know: -features of a chromosome (homologous vs. non-homologous chromosomes, sister chromatids, centromere, etc) -structure of human X and Y chromosomes, along with process of sex determination in humans - mechanisms of sex determination in species other than humans (e.g. Drosophila and birds) -phases of cell cycle and stages of mitosis (P 2 MAT) -stages of meiosis, including process of synapsis (recombination). You do not need to memorize the names of stages within prophase I (leptotene, etc) -be able to determine number of chromosomes, centromeres, chromatids, tetrads, and/or dyads at various stages of mitosis and meiosis -know the differences between mitosis and meiosis (Table 4.3 in Hartwell et al.) -know how meiosis generates genetic diversity and provides a physical basis for Mendel’s Laws -nature of X-linked inheritance patterns. Be able to determine outcomes (both phenotypes and genotypes) of crosses involving X-linked genes and be able to work backwards from progeny to parent -phenotypic outcomes of non-disjunction during meiosis -be able to combine independent assortment of autosomal and X-linked genes -be able to predict from a pedigree, whether a genetic disease is autosomal recessive or dominant, X-linked recessive or dominant, or Y-linked. Be able to predict likely genotypes of individuals on a pedigree. Also, be able to predict the probabilities that a person will develop
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Genetics problem set - Lecture 4: Chromosomal Basis of...

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