L01_02-20112 -...

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Cell Biology (BIOL 2020): Exploring the structure and function of  cells Dr. Darryl L. Kropf [email protected] Office 203 G South Biology Office Hour -  W 3-4  pm Essential Cell Biology Third Edition
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HARDCOVER ISBN: 978-0-8153-4129-1:$139.00 NEW E-BOOK OPTIONS E-book: $97.00 1 year e-rental: $83.00 180 day e-rental: $69.00 To purchase or rent e-books visit: http://store.vitalsource.com/show/978-0-2038-2820-5      Essential Cell Biology Third Edition  Alberts Bray Hopkin Johnson Lewis Raff Roberts Walter
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Teaching Assistants
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Go to Discussions! Discussions will focus on working problems rather than memorization Discussions start next week
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Biology Honors Research
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What is a “Cell?” I took a good clear piece of cork, and  with a Pen-knife sharpen’d as keen  as a Razor, I cut a piece of it off…  then, examining it with a  Microscope , me thought I could  perceive it to appear a little porous Robert Hooke 1655 Hooke named the porous structures he saw  (the walls of the cork cells)  cellulae   because they reminded him of monks’ cells  in a monastery
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Cells come in a variety of sizes and shapes Yet all cells have same basic chemistry (DNA, RNA, proteins etc.)
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The “Cell Theory” of life has 3 postulates ECB 1-3 In 1839, zoologist  Theodor Schwann  observed that animals were made of cells, and proposed: 1.  All organisms are composed of cells; and 2. Cells are the structural unit of  life In 1855, pathologist  Rudolf Virchow  added: 3. Cells arise only from other cells* So what is life????
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So what is life? FM Harold - “The Way of The Cell” Complex organization Metabolism Reproduce Adapt to environment FM Harold - “Autopoietic systems capable of evolution by natural selection” (autopoietic - capable of making themselves) ECB - Highly organized Homeostasis (constant internal environment) Reproduce Grow and develop Take energy from environment Respond to stimuli Adapt to environment Biologists generally agree that living cells must have 1. A limiting boundary (plasma membrane) 2. A mechanism of inheritance (RNA, DNA) 3. Carry out complex metabolism (chemical reactions)
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Are viruses alive? A comparison of viruses,  prokaryotes, and eukaryotes Viruses Prokaryotes Eukaryotes            Size ~50-500 nm ~0.3-5  μ m > 5  μ m Influenza virus E. coli Human  lymphocytes ECB figure 1-25 ECB figure 1-25 Nucleic acid and a few  proteins (protein coat)
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Viruses lack basic machinery for self replication and are  dependent on HOST cell  functions for their propagation Viruses also lack extensive metabolism Both prokaryotic and eukaryotic cells contain machinery for  autonomous  reproduction and carry out extensive metabolism Learn more about viruses in our microbiology courses
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This note was uploaded on 02/01/2011 for the course BIO 2020 taught by Professor Kropf during the Spring '11 term at University of Utah.

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L01_02-20112 -...

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