Chapter+52(2010) - PNR 182 CHAPTER 52 IMMUNOSTIMULANT DRUGS...

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PNR 182 CHAPTER 52 IMMUNOSTIMULANT DRUGS SPRING 2010 D. Collins
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REVIEW OF HEMATOPOIETIC SYSTEM 3 cells that circulate in the blood: RBC – supply cells with oxygen WBC – protect from dangerous microorganisms Platelets – control bleeding Chronic diseases(kidney) or medical treatments(chemo) can cause failure. When this happens, inadequate numbers of cells are produced resulting in the body no longer meeting the demands of oxygen transport, blood coagulation, or prevention of invasion of microorganisms. This in turn can cause anemia, bleeding, or infection. Hematopoietic drugs are used to treat these problems. The goal is to stimulate the body to make more specific blood cells.
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HEMATOPOIETIC DRUGS USED IN TREATING POTENTIAL BLEEDING OR INFECTION NEUTROPHIL One of the major WBC in the line of defense from infection. Neutropenia – condition that results when the neutrophil level in the blood is low. Infection is likely to occur when this happens. Extremely short life span(6-8 hours) resulting in rapid growth & division. A target of cancer chemotherapy drugs, as well as cancer cells themselves. Chemotherapy-induced neutropenia is a major reason cancer treatments may be delayed or cancelled.
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COLONY STIMULATING FACTORS Drugs used to stimulate growth & production of WBC’s to help fight off infection. These drugs act on the hematopoietic cells to stimulate proliferation, differentiation, & maturation of WBC’s. Used to treat infection associated with chemotherapy- induced neutropenia, neutropenia during bone marrow transplant, production of stem cells for harvest before transplant, & neutropenia in those susceptible to chronic infection.
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EXAMPLES OF DRUGS Neupogen – started at least 24 hours after completion of cycle of chemo. Not recommended for use longer than 2 weeks. Treatment D/C’d at least 1 week before next chemo. Neulasta – similar to Neupogen but given as a single dose between chemo cycles. Leukine – used following BMT & to stimulate stem cells for harvest.
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Bone pain, HTN, N/V, Alopecia, Hypersensitivity/Allergic Reactions CONTRAINDICATIONS/PRECAUTIONS Neupogen – cautiously in pts. with hypothyroid disease or when pt. breastfeeds Neulasta – can cause sickle cell crisis All CSF can cause hypersensitive reactions & an even higher ↑ in neutrophil count can occur when these drugs are taken with lithium.
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This note was uploaded on 02/01/2011 for the course PNR 182 taught by Professor Toole during the Spring '10 term at Orangeburg-Calhoun Technical College.

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Chapter+52(2010) - PNR 182 CHAPTER 52 IMMUNOSTIMULANT DRUGS...

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