BME 314 Lecture 5 2010

BME 314 Lecture 5 2010 - Tissue Engineering Krish Roy,...

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Unformatted text preview: Tissue Engineering Krish Roy, Ph.D. Associate Professor Dept. of Biomedical Engineering The Materials Science connection: Scaffolds Provide mechanical support for cells Permanent - e.g. extracorporeal therapies Controlled degradation - scaffolds that go away when they are not needed! Promoters of cell adhesion, differentiation and function Surface properties Controlled drug/protein delivery (spatial distribution, release profile, sequential release) 3D structure (morphology affects function) Scaffolds can help to signal cell differentiation Attachment Proliferation & Differentiation Tissue Deposition Tissue maturation Soluble growth factors Cell-cell interactions Mechanical stimuli Cell-substrate interactions Electrical stimuli Time Process seconds weeks Substrate 100 nm to 10 cm Other scaffolding considerations http://www.btec.cmu.edu/research/engineering/sff/sff.htm Vascular supply Cell seeding Gradients of growth factors Spatial gradients of cells Spatial gradients of materials Materials in Tissue Engineering Use of biomaterials in TE Primary application is to provide the supporting environment for the optimal growth and differentiation of regenerating and/or seeded cells SCAFFOLDS Generally three-dimensional structures designed according to physical and biological principles conducive of cell attachment, migration, growth and differentiation Materials could be natural or synthetic, mostly polymers and ceramics but also metals Materials are often modified and designed according to bio- mimetic principles the goal is to mimic nature , knowledge...
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This note was uploaded on 02/01/2011 for the course BME 314 taught by Professor Frey during the Spring '08 term at University of Texas.

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BME 314 Lecture 5 2010 - Tissue Engineering Krish Roy,...

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