BME 314 Lecture 21 2010

BME 314 Lecture 21 2010 - CdSe crystals viewed from...

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Biomedical Optics: Applications Biomedical Optics: Applications Krish Roy, PhD Associate Professor Department of Biomedical Engineering
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In-situ fluorescen In-situ fluorescen ce spectroscopy ce spectroscopy o o f f tissue tissue Early Diagnosis of Early Diagnosis of Cancer Cancer Fluorescence or reflectance spectrum of healthy tissues differ from that of cancerous tissue. Shine light on a tissue Collect the fluorescence or reflectance signal Analyze
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Nanomaterials Nanomaterials in Biomedical Optics in Biomedical Optics
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Nanomaterials Nanomaterials Generally: materials that are between 10-100 nm Anything less than 1 micron is considered nano, but realistically it should be at least less than 500 nm Wide range of applications: Drug delivery, cell engineering, diagnostics, sensors etc. E.g.: nanoparticles, quantum dots, carbon nanotubes, nanowires, gold and silica nanoshells etc.
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Quantum Dots as Sensors Quantum Dots as Sensors What are quantum dots? Small semiconductor single-crystals of a few nm size Size controlled by the synthesis conditions
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Unformatted text preview: CdSe crystals viewed from different crystal axis Alivisatos, A. P.: Science 271 , 933 (1996) Michalet, X.: Science 307 , 538 (2005) Quantum Dots as Sensors Quantum Dots as Sensors Quantum dots: Also known as nano-crystals. Highly versatile semi-conductors Color of luminescence is dependent on particle size. Generally used in a core-shell configuration Quantum Dots as Sensors Quantum Dots as Sensors Tuning the wavelength by size: Chan, W. C. W.: Curr. Op. Biotech 13 , 40 (2002) Quantum Dots as Sensors Quantum Dots as Sensors A great fluorophore: Emission: symmetric narrow Chan, W. C. W.: Curr. Op. Biotech 13 , 40 (2002) Rhodamine = red fluorescent dye Quantum Dots as Sensors Quantum Dots as Sensors Broad-band absorption: Absorption: open to higher energies excitation at one wavelength for several colors. excitation far from emission possible. Chan, W. C. W.: Curr. Op. Biotech 13 , 40 (2002)...
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BME 314 Lecture 21 2010 - CdSe crystals viewed from...

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