ex30 - Harjit Kaur Che 202 Grignard Synthesis of...

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Harjit Kaur Che 202 Grignard Synthesis of Triphenylmethanol I A. The purpose of this experiment was to synthesize triphenylmethanol. The resulting “Grignard reagent” acts as both a good nucleophile and a strong base. Its nucleophilic character allows it to react with the electrophilic carbon in a carbonyl group, thus forming the carbon-carbon bond. Its basic property means that it will react with acidic compounds, such as phenols, thiols, alcohol, amines and water, to generate the therefore, reaction conditions must be free from acids and strictly anhydrous. Grignard reagents will also react with oxygen to form hydroperoxides, thus they are highly unstable when exposed to the atmosphere and are generally not isolated from solution. The magnesium metal used in the synthesis contains a layer of oxide on the surface that prevents it from reacting with the alkyl bromide. In the experiment bromobenzene is the alkyl bromide used to make the Grignard reagent and the electrophilic compound is the carbonyl group of benzophenone. B. II A. Into a 3-ml conical vial, 3.80mmol of benzophenone was dissolved in 2.0ml of anhydrous ethyl ether. When the reaction cooled, after the ether stops boiling, the septum
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ex30 - Harjit Kaur Che 202 Grignard Synthesis of...

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