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Lecture 11_17 - Main Points Cancer is a cell cycle defect...

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2/3/11 Main Points Cancer is a cell cycle defect Cancer results from the accumulation of mutations There are 2 classes of genes that contribute to cancer Oncogenes Tumor suppressors
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2/3/11 Fig. 12-14 S G 1 M checkpoint G 2 M Control system G1 checkpoint G2 checkpoint
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2/3/11 Fig. 12-15 G 1 G 0 G1 checkpoint (a) Cell receives a go-ahead signal G 1 (b) Cell does not receive a go-ahead signal
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2/3/11 Normal cells pay close attention to external and internal signals so they divide only when they are supposed to. Some signals are: Growth factors DNA damage Chromatids bound to kinetochore A cancer cell has two characteristics: 1. ignores normal cell cycle controls 2. invades spaces that belong to other cells.
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2/3/11 Figure 20-3 Molecular Biology of the Cell (© Garland Science 2008)
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2/3/11 Figure 20-9 Molecular Biology of the Cell (© Garland Science 2008)
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2/3/11 Figure 20-11 Molecular Biology of the Cell (© Garland Science 2008)
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2/3/11 Genes and cancer There are two broad categories of genes that lead to cancer when mutated: Proto- Oncogenes Tumor suppressors
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2/3/11 How does a cell come to have an Oncogene?
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