Lecture11_5 - Main Ideas Mutagens Relationship between...

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2/3/11 Main Ideas Mutagens Relationship between mutations and human disease. Relationship between mutations and gene regulation.
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2/3/11 Mutagens Spontaneous mutations Physical mutagens X-rays UV light Chemical mutagens Base analogs (caffeine, morphine, nicotine) Intercalating agents (ethidium bromide)
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2/3/11 If you go to a tanning salon, you will be exposed to ionizing radiation that might cause mutations. Where do you think you might see the affects of those mutations? Do you think the mutations would be heritable (would your children have them)?
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2/3/11 If you ingested a chemical mutagen and it caused mutations in cells of your ovaries or testes, would the mutations be heritable?
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2/3/11 Examples of Mutations Cystic fibrosis Sickle Cell Anemia Trinucleotide expansion diseases Parkinson’s Disease Master regulatory genes
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2/3/11 Cystic Fibrosis AUCAUCUUUGGUGU U… Ile Ile Phe Gly Val AUCAUUGGUGU U… Ile Ile Gly Val 3 base deleti on
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2/3/11 How does the mutation lead to disease? On what part of the DNA is the mutation
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This note was uploaded on 02/02/2011 for the course BIO 311C taught by Professor Satasivian during the Fall '08 term at University of Texas.

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Lecture11_5 - Main Ideas Mutagens Relationship between...

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