Lecture11_12 - 2 Cyclin accumulation MPF phosphorylates...

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2/3/11 Cell cycle control Cell cycle clock Cyclin dependent kinases Anaphase promoting complex and ubiquitination Cell cycle checkpoints External and internal signals Exiting the cell cycle
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2/3/11 Fig. 12-5 S (DNA synthesis) MITOTIC (M) PHASE Mitos is Cytokinesi s G1 G2 INTERPHASE
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2/3/11 Figure 17-9 Molecular Biology of the Cell (© Garland Science 2008)
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2/3/11 Figure 17-14 Molecular Biology of the Cell (© Garland Science 2008)
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2/3/11 Active protein Cellular response
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2/3/11 Figure 17-15 Molecular Biology of the Cell (© Garland Science 2008)
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2/3/11 Fig. 12-17a Tim e (a) Fluctuation of MPF activity and cyclin concentration during the cell cycle Cyclin concentratio n MPF activity M M M S S G 1 G 1 G 1 G 2 G 2 MPF is a protein complex between a cyclin dependent kinase and M-cyclin. It phosphorylates proteins involved in mitosis to activate them.
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2/3/11 Fig. 12-17b Cyclin is degrade d C dk M PF Cd k M S G 1 G2 checkpoi nt Degrade d cyclin Cycl in (b) Molecular mechanisms that help regulate the cell cycle
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Unformatted text preview: 2 Cyclin accumulation 2/3/11 MPF phosphorylates proteins which lead to the transition between G2 and M phases. What are some events that occur during mitosis that depend on MPF activity? 2/3/11 Figure 17-16 Molecular Biology of the Cell (© Garland Science 2008) 2/3/11 Figure 17-20a Molecular Biology of the Cell (© Garland Science 2008) 2/3/11 Figure 17-14 Molecular Biology of the Cell (© Garland Science 2008) 2/3/11 Figure 17-21 Molecular Biology of the Cell (© Garland Science 2008) 2/3/11 Fig. 12-15 G 1 G G1 checkpoint (a) Cell receives a go-ahead signal G 1 (b) Cell does not receive a go-ahead signal 2/3/11 Figure 17-69 Molecular Biology of the Cell (© Garland Science 2008) 2/3/11 2/3/11 Fig. 12-19 Anchorage dependence Density-dependent inhibition Density-dependent inhibition (a) Normal mammalian cells (b) Cancer cells 25 μm 25 μm...
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