Lecture12_1 - 2/3/11 Main Ideas A signal must be received...

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Unformatted text preview: 2/3/11 Main Ideas A signal must be received to be meaningful: the four common types of receptors. A signal received by a membrane- bound receptor must be transduced. Sometimes transduction involves a series of phosphorylation events. Sometimes transduction involves a second messenger: cAMP and IP3 2/3/11 Fig. 11-6-3 EXTRACELLUL AR FLUID Plasma membrane CYTOPLA SM Recept or Signali ng molecul e Relay molecules in a signal transduction pathway Activati on of cellular respons e Recepti on Transducti on Respon se 2 3 4 1 Signalin g Steps of Cell Communication 2/3/11 Four common types of receptors Receptor tyrosine kinases G protein-coupled receptors Ion-channel receptors Steroid hormone receptors 2/3/11 Fig. 11-7c Signaling molecule (ligand) Ligand-binding site X Heli x Tyrosin es T y rT y rT y r T y rT y rT y r Receptor tyrosine kinase proteins CYTOPLA SM Signali ng molec ule T y rT y r T y r T y rT y rT y r T y rT y rT y r T y rT y rT y r Di mer Activated relay proteins T y rT y rT y r T y rT y rT y r P P P P P P Transduction and Cellular response 1 Transduction and Cellular...
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Lecture12_1 - 2/3/11 Main Ideas A signal must be received...

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