chap_7-2

chap_7-2 - repair proteins affect human health Xeroderma...

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DNA repair mechanisms Enzymes Photolyase Simple repair systems Base excision repair Nucleotide excision repair Methyl-directed mismatch repair Error-prone repair systems SOS system Nonhomologous end-joining simple complex Chapter 7 Part II Quiz #2 next Tuesday
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Photolyase Breaks thymine dimers
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Base excision repair Deaminated DNA with uracil Glycosylase removes uracil Endonuclease cuts backbone Exonuclease removes nucleotides near the nick DNA polymerase makes new DNA to fill the gap Ligase seals the nick
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Nucleotide excision repair
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Fig. 7.13 Methyl-directed mismatch repair
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Methyl-directed mismatch repair (cont.) MutS MutL MutH
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SOS system Includes “sloppy” DNA polymerases Detects stalled DNA replication Add random nucleotides across from the damaged bases Only works 25% of the time!
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Non-homologous end-joining Results in deletions!
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Mutations in genes encoding DNA
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Unformatted text preview: repair proteins affect human health Xeroderma pigmentosum Mutation Clicker: A defect in which repair mechanism likely leads to Xeroderma pigmentosum? 1. Base excision repair 2. Nucleotide excision repair 3. Methyl-directed mismatch repair 4. SOS system 5. Nonhomologous end-joining The Ames test A test for carcinogens using his-mutants of Salmonella typhimurium Fig. 7.16 Genes encode polypeptides Proteins are made of polypeptides (1 or more) Monomer = Amino acid: Fig. 7.24 a Amino (-NH2) group Peptide bonds are formed via: Dehydration reactions Fig. 7.24 c Protein structure Fig. 7.26 Quarternary structure: ____________________ Fig. 7.27 How do genotypes and phenotypes correlate? Fig. 7.25 a Different amino acid substitutions lead to different phenotypes Fig. 7.25 c...
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This note was uploaded on 02/03/2011 for the course BIOL 2153 taught by Professor Larkin during the Fall '03 term at LSU.

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chap_7-2 - repair proteins affect human health Xeroderma...

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