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chap_8-2 - Prokaryote vs Eukaryote mRNA Prokaryote Gene(DNA...

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Prokaryote vs. Eukaryote mRNA Prokaryote Eukaryote transcription Gene (DNA) Primary transcript (RNA) translation transcription RNA processing Mature mRNA translation polypeptide
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Brainstorm What are examples of mRNA processing in eukaryotes? 5’ Methylated Cap Poly-A-Tail RNA splicing remove introns Alternative splicing
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5’ Methylated Cap Step 1: “Backward” G is added by a special capping via a triphosphate bridge Step 2: methyl transferase adds methyls to G and 1+ succeeding nucleotides Fig. 8.13
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3’ Poly-A-Tail Fig. 8.14 Step 1: ribonuclease cuts mRNA 11-30 nucleotides downstream of AAUAAA (recognition element) Step 2: poly-a-polymerase adds multiple A’s onto 3’ end Step 1 Step 2
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Methylated Cap and poly-A tail stabilize mRNA 5’ cap Translation initiation factor AAAA Poly-A binding protein
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RNA splicing removes introns Exons – sequences found in a gene’s DNA and mature mRNA (ex pressed regions) Introns – sequences found in DNA but not in mRNA (in tervening regions) Some eukaryotic genes have many introns
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Fig. 8.16 RNA SPLICING
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