chap_14-1

chap_14-1 - Chapter 14, Part I Chromosomal Rearrangements...

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Chapter 14, Part I Chromosomal Rearrangements Assignment: Chapter 14 problems: 29, 30, 35, 36 Mouse chromosome 1 contains large blocks of DNA found on 7 human chromosomes Q- long arm of chromosome
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Chromosomal Rearrangements Deletions Duplications Inversions Translocations Arise from: 1) Replication errors 2) Recombination errors 3) Damaging agents (e.g. X-rays)
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Deletions (X-ray) remove genetic material from genome Homozygous mostly lethal Heterozygous usually has no phenotype (if small; i.e. a few genes) large deletions can be lethal Why? Genetic imbalance (dosage effect) Knock out one gene (pair) then causes imbalance Several genes lost
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Deletions can “uncover” genes Hemizygous = only 1 copy of an allele Similar to heterozygous Red eye (st + /st + or st + /st) Scarlet eye (st/Del) Pseudodominance = appearance of a recessive phenotype due to the absence of an allele Recessive mutation
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Duplications add material to the genome Tandem vs. nontandem (i.e.
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chap_14-1 - Chapter 14, Part I Chromosomal Rearrangements...

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