chapter_17-1

chapter_17-1 - Chapter 17, Part I Prokaryotic Gene...

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Chapter 17, Part I Prokaryotic Gene Regulation Chapter 17 Problems: 5, 7, 8, 10, 12, 22, and 29
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Vibrio cholerae Infectious gastroenteritis Ingesting contaminated food or water Infected patients can die within three hours Enter stomach V. cholerae cells limit protein synthesis Move to small intestine bacteria secrete proteases to break down the mucosal lining Reach the intestinal epithelial cells stop making flagellin; make and secrete toxin Toxin depletes cells of chloride ions; secrete water; severe dehydration All possible because of gene regulation!
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Gene Expression RNA
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Gene Regulation Control of gene expression processes Transcriptional 1. Binding of RNA polymerase to promoter 2. Shift from transcriptional initiation to elongation 3. Release of the mRNA at termination Post-transcriptional 1. mRNA stability 2. Efficiency of ribosomes recognizing translational signals 3. Polypeptide stability The key regulation step for most bacterial genes is the binding of RNA polymerase to DNA promoter
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Lactose utilization in E. coli : Classic model for gene regulation E. coli need sugar as a source of carbon and energy
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chapter_17-1 - Chapter 17, Part I Prokaryotic Gene...

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