chap_18-1

chap_18-1 - Promoter Close to genes transcription...

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Chapter 18, Part I Eukaryotic Gene Regulation Chapter 18 Problems: 2, 3, 5, 6, 8
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Eukaryotic gene regulation I Components o cis -acting elements o trans -acting factors Control of transcription initiation o RNA polymerases RNA Pol I RNA Pol III RNA Pol II o cis elements Promoters Enhancers o trans factors Basal factors Activators and repressors
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Components cis -acting elements ______________________ DNA sequence where RNA polymerase binds ______________________ DNA sequence where regulatory proteins bind trans -acting factors (i.e. transcription factors) ______________________ Bind promoter ______________________ Bind enhancers
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RNA polymerase I ________________________
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RNA polymerase III Each tRNA gene has an atypical internal promoter What are snRNAs (“_________________ ”) used for? __________________________________
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RNA polymerase II _________________________________
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Class II gene components cis -acting elements
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Unformatted text preview: Promoter Close to genes transcription initiation site ____________________________ Enhancer Can lie far away from gene Can bind many types of transcription factors TATA(A/T)A(A/T) trans-acting factors (transcription factors) Basal factors Assist the binding of RNA pol II to the promoter Activators and repressors Bind enhancer elements Class II gene components Basal factors TBP ___________________ Key component of basal factor complex TAF TBP-Associated Factors Why called basal factors? Activators and repressors Bind enhancer Can have positive (activator) or negative (repressor) effect on transcription Coactivator and corepressor RNA Pol Basal factors Activator Co-activators 2 mechanisms of repression Competition and quenching Transcription complex and enhancers movie...
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This note was uploaded on 02/03/2011 for the course BIOL 2153 taught by Professor Larkin during the Fall '03 term at LSU.

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chap_18-1 - Promoter Close to genes transcription...

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