4 Neurotransmitters - Chemical Transmission Reading Squire...

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Golgi Cajal Chemical Transmission Reading: Squire ch 7
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Otto Loewi & Henry Dale shared the 1936 Nobel prize for “ discoveries relating to chemical transmission of nerve impulses"
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Conditioned media Cultured neurons ???? Goldin et al. (2001) Transfer of conditioned media (CM) changes electrical firing patterns of neurons structural morphology of dendritic spines
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Criteria used to designate a substance as a neurotransmitter 1. The substance must be synthesized and released by neurons. 2. Release should be from nerve terminals. 3. Putative neurotransmitter should reproduce postsynaptic cell-specific responses analogous to those observed upon stimulation of the presynaptic neuron. 4. The effects of the putative neurotransmitter should be blocked by a known competitive antagonists in a dose-dependent manner. 5. There should be active mechanisms to terminate the actions of the putative neurotransmitter.
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Chemical neurotransmission involves five steps 1. Biosynthesis of neurotransmitter in the presynaptic neuron.
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