addiction ALCOHOL METABOLISM

addiction ALCOHOL METABOLISM - like blood, will get more;...

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ALCOHOL METABOLISM Ingestion: Stomach : metabolism begins mouth men vs. women throat food-milk-aspirin impact esophagus: greater risk absorption begins for cancer in heavy alcohol users Small intestine: more absorption Ethanol absorbed from stomach and small intestine go in to blood and then to cells of the body: notably the lungs, liver, and brain; absorption affected by food, milk, per cent of alcohol, carbonation, and aspirin. Peak concentration levels occur in ~30-90 minutes; tissues with higher water content,
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Unformatted text preview: like blood, will get more; ethanol is soluble in fat, and women tend to have higher % of fat. Liver is primary location for metabolism. Liver uses CYP2E1. Rate of metabolism is set at an amount per unit of time, and varies with age, and tolerance. Steps in metabolism: Alcohol ALCOHOL DEHYDROGENASE (ADH) Acetaldehyde ACETALDEHYDE DEHYDROGENASE (ALDH) (ANTABUSE, DISULFIRAM) Acetic acid OXIDIZED CO2 (lungs) + H2O (urine) + energy Excretion occurs mainly in the liver and lungs (non-metabolized)....
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