addiction ch 9 Glutamate

addiction ch 9 Glutamate - Glutamate&Alcohol Glutamate:

Info iconThis preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
   Glutamate: - Excitatory NT in nervous system - Many cells in CNS have receptors - NMDA (N-Methyl-D-Aspartate)- receptor that allows  Na+ and Ca++ to enter - These ions depolarize membranes of post-synaptic cells  (hippocampus implicated in  Alcohol inhibits glutamate effectiveness at NMDA receptors and reduces glutamate release!  (may explain black–outs).   With repeated ethanol use, brain compensates for decrease in glutamate activity by  increasing # of NMDA receptors (up-regulation) (hippocampus, cortex). If stop alcohol, within about 10 hours, it is believed that glutamate release rebounds –  more glutamate and more receptors. This corresponds to time for possible seizures during  withdrawal. Also an increase in Ca ++ activity may contribute to some cell death. Frequent attempts 
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 2
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 02/05/2011 for the course PSY 477 taught by Professor Ceasar during the Spring '11 term at CSU Long Beach.

Page1 / 2

addiction ch 9 Glutamate - Glutamate&Alcohol Glutamate:

This preview shows document pages 1 - 2. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online