addiction opioids

addiction opioids - mu in locations • Being in the...

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Opiates/Opioids Multiple opioid receptors Multiple opioid receptor sites-brain, brain stem, spinal cord, digestive system, many organs While similar to endogenous opioids, opioid/opiate drugs cause more intense reactions Each drug has its unique affinity for receptor sites
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Opioid Receptors Three main opioid receptors called mu, kappa, delta; probably metabotropic Mu is widely distributed in brain and spinal cord areas resulting in analgesia, positive reinforcement, cardiovascular and respiratory depression, cough control, nausea, vomiting (brain stem)
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DeltaReceptors Delta receptors are more restricted than
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Unformatted text preview: mu in locations • Being in the neocortex, substantia nigra, nucleus accumbens, and olfactory areas, what results would you expect? Kappa Receptors • Distinct and limited distribution • Found in sub-cortex areas that regulate bodily functions like water balance, temperature control, neuroendocrine function • Hormonal systems impacted resulting in male decrease in testosterone and delayed periods in women Side effects • Slurred speech • Poor coordination • Pinpoint pupils* • Suppressed cough (for whom might this be a disadvantage?) • Constipation* • *Little tolerance develops...
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This note was uploaded on 02/05/2011 for the course PSY 477 taught by Professor Ceasar during the Spring '11 term at CSU Long Beach.

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addiction opioids - mu in locations • Being in the...

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