addiction Wernicke

addiction Wernicke - damage results in poor coordination....

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Wernicke-Korsakoff Syndrome Thiamine (necessary for glucose metabolism in the brain) is more difficult to absorb under heavy alcohol use. Also, many alcoholics do not eat well which exacerbates the problem. Eventually, lack of thiamine results in manifestations of confusion, disorientation, and poor coordination. This deterioration can stop with thiamine if alcohol is discontinued. Damage is not reversed if it has occurred. In later stages of the disease, memory of recent events is lost, there is cell loss in the thalamus and mamillary bodies. Other brain areas show cell loss which do not appear to be due to diet deficiency. Brain tissue shrinks due to cell loss. The ventricles appear enlarged. Frontal lobes are affected. Other loss occurs in the temporal lobes, including the hippocampus and cholinergic cells in the forebrain contribute to memory loss. Cerebellar
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Unformatted text preview: damage results in poor coordination. Alcohol dilates peripheral blood vessels bringing them closer to the surface resulting in flushing and warm skin. Heat is released. Vasodilation in the brain from one drink may help cognition in older adults able to metabolize sufficiently. Alcohol Treatment Medications Antabuse (disulfiram) : used by people in recovery who are abstinent and motivated to stay that way. People need to completely avoid even small amounts of alcohol since the Antabuse intake prevents metabolism of acetaldehyde. Revia (naltrexone) : also helpful for people who want to be abstinent; believed to reduce the pleasure/reward from the alcohol ingestion; is an opioid antagonist. Acamprosate : probably has an effect on GABA receptors Buspar (buspirone) : impacts serotonin; reduces anxiety....
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addiction Wernicke - damage results in poor coordination....

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