ch 3 drug nervous sys ppt & lecture

ch 3 drug nervous sys ppt & lecture - Ch.3 Nervous...

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Ch.3 Nervous System Myelin-fatty white substance covering some axons; increases speed of electrical impulse; if deteriorates, results in a disease. Action potential-when neuron is “stimulated” at its dendrites’ receptors, changes can occur within the cell and along the axon, resulting in nueron’s firing;electrical impulse along the axon when neuron fires. Myelin-fatty white substance covering some axons; increases speed of electrical impulse; if deteriorates, results in disease.
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Axon Terminals Axon terminals/buttons-at ends of axons Synapse- junction between neurons Neurotransmitters-chemicals stored vesicles and axon terminals and released into synapse when neuron fires;influence postsynaptic neurons.
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Receptors Ionotropic-couple to ion channels;can open channel; if enough receptors opened, creates change like + ions coming into cell creating an action potential=excitatory; fast Metabotropic Receptors Results in activation of a specialized molecule (second messenger) like a G- protein; slow This messenger then impacts other activities within the cell
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Antagonist A substance that occupies a neuron’s receptor and BLOCKS/ does not activate normal synaptic transmission naloxone/Narcan) is opiate antagonist
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Agonist Agonist-a substance that occupies a neuron’s receptor and activates it and causes some change in the neuron This may be a natural substance or something foreign Anandamide and marijuana Endorphin and heroin
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Neurotransmitters (NTs) Psychoactive drugs (PD) need to mimic NTs so they will have a place to “reside” in the body and brain. Some NT increase neuron cell firings by their impact on the receptors=excitatory. Some decrease=inhibitory. Each nerve cell produces and sends one NT and can have receptors for several NT Stored in vesicles; reuptake
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NT Names Acetylcholine (ACh)- active at nerve-muscle junctures, ANS ganglia, and CNS
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ch 3 drug nervous sys ppt & lecture - Ch.3 Nervous...

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