lecture 6 neurotransmitters 1

lecture 6 neurotransmitters 1 - 9/22/2008...

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9/22/2008 1 Lecture 6: Neurotransmitters I Overview 1 Review 1. Review 2. Presynaptic effects 3. Postsynaptic receptors 4. Termination of neurotransmitter release 5. Amino acid neurotransmitters 6. Acetylcholine 7. Monoamine neurotransmitters 8. Neuropeptides Review Propagation o the neural impulse is faster and more efficient in myelinated neurons because of saltatory conduction. At the terminal button, arrival of the action potential activates voltage gated calcium channels which results in an influx of voltage gated calcium channels, which results in an influx of calcium and fusion of vesicles with the presynaptic membrane that contain neurotransmitter molecules. Neurotransmitter molecules released travel passively through the synaptic cleft and interact with postsynaptic receptors (ligand gated receptors) that either have an inhibitory (IPSP) or excitatory effect (EPSP) of the membrane potential of the postsynaptic neuron. EPSPs and IPSPs are graded potentials and either increase or decrease the likelihood that the postsynaptic neurons fires an action potential (Summation effects are important – i.e., when and where are graded potentials)
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9/22/2008 2 Neurons are specialized cells designed to transmit information Agents of Synaptic Transmission: 1. Small Molecule Neurotransmitters Amino acids–most numerous Glutamate (excitatory) gamma amino butyric acid (GABA) (inhibitory) aspartate glycine Acetylcholine–f irst discovered Monoamines – derived from an amino acid catecholamines epinephrine (adrenalin) norepinephrine (noradrenalin) dopamine indoleamines serotonin melatonin
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9/22/2008 3 Soluble gases it i id Agents of Synaptic Transmission: 1. Small Molecule Neurotransmitters nitric oxide
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This note was uploaded on 02/05/2011 for the course PSY 370 taught by Professor Zalava during the Fall '09 term at CSU Long Beach.

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lecture 6 neurotransmitters 1 - 9/22/2008...

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