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lecture 19 drug abuse 3

lecture 19 drug abuse 3 - Lecture 19 Drug Abuse III...

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12/3/2008 1 Lecture 19 : Drug Abuse III Overview Review Alcohol Benzodiazepines and Barbiturates Psychostimulants Psychostimulants Psychostimulant —A drug that produces alertness by enhancing the functioning of the sympathetic nervous system and the reticular formation. f h l Four types of psychostimulants: % amphetamine % cocaine % caffeine % nicotine
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12/3/2008 2 % Amphetamine % Increase in alertness and decreased sleep Amphetamines Amphetamine and related psychostimulants (e.g., methamphetamine) resemble the neurotransmitter DA in their chemical structure. % Increased focus (sustained attention tasks) % Reduced appetite % Positive affect (mood) % Low doses very effective % High doses interfere with performance and concentration % Sid ff t f h t i Side effects of amphetamines: % dysphoria % Hypersomnia (2 3 days) % Stereotypy (teeth grinding) % Restlessness % Paranoia % Inflated self importance % Narcolepsy % ADHD (Attention Deficit/Hyperactivity Disorder) % Weigh loss Clinical Use of Amphetamines Mechanisms of Amphetamine Action % AMPH and METH are indirect agonists % cause DA molecules to be release into cytoplasm of nerve t i l terminal % these DA molecules are then transported outside of the terminal by a reversal of DAT % resulting in massive increase in synaptic DA concentrations
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12/3/2008 3 Mechanisms of Amphetamine Action % AMPH and METH are indirect agonists %
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