Exam1b - Biology of Cancer and AIDS Exam 1B_Key Instructor...

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Page 1 of 8 Biology of Cancer and AIDS Exam 1B_Key Instructor: Wilmore Webley, Ph.D. Instructions: Please fill out the appropriate fields with your name and ID# on your answer sheet. Choose the best single answer to each question and shade it in on your answer sheet. 1. Tumor grade is important in determining the prognosis of an individual's cancer. How is tumor grade determined? (A) Microscopic appearance of cells (B) Location in the body (C) Extent of tumor spread (D) How well it does on exams 2. Choose the most accurate description about the initiation of most cancers. (A) Many cells in a certain locale acquire single mutations and work together to form a tumor (B) Multiple cells develop multiple mutations and synergistically form a tumor. (C) A single cell undergoes multiple mutations over time, proliferating to form a tumor (D) A single mutation in any cell grows rapidly to form a tumor. 3. Cellular differentiation is an important part of a pathologist’s tool to understanding and diagnosing cancer. The more differentiated a tissue appears, the _______________. (A) lower the chances of rapid cell division (B) greater the likelihood of cancer development (C) lower the likelihood of metastatic cancer (D) higher the rate of DNA damage 4. Which of the following most adequately describes why a combination of cigarette smoke and alcohol use increases cancer risk so significantly? (A) Alcohol causes mutation, cigarette smoke causes mutated cells to proliferate (B) Alcohol prevents nicotine from being inactivated by the immune system (C) Smoke causes DNA mutations and alcohol stimulates proliferation of damaged cells (D) Alcohol is converted into a carcinogen by cigarette smoke (E) It is a myth that smoking and drinking increases cancer risk 5. Vascular endothelial growth factor is typically released by malignant tumors in order to________. (A) evade the immune system (B) stimulate differentiation (C) enhance hyperplasia (D) stimulate angiogenesis
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Page 2 of 8 6. We discussed the life of Dr. Judah Folkman and the important contributions he made to the field of cancer biology before passing away in January of 2008. What was Dr. Folkman's major contribution? (A) He discovered the role of angiogenesis in cancer spread (B) He discovered the link between infectious agents and cancer (C) He catalogued the complete profile of cancer cells (D) He discovered that DNA damage eventually leads to cancer 7. Cancers are able to evade the immune system because of certain characteristics of cancer cells. Which of the following is NOT a reason for immune evasion of cancer? (A) Natural selection favors cancer cells that induce strong immune response (B) Tumor cells look like normal host cells (C) Cancer cells surround themselves with dense connective tissue (D) Some cancers divide so quickly that they overwhelm the immune system 8. In which of the following cells would you expect the greatest expression of telomerase? (A) Developing embryo and metastatic cancer cells
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Exam1b - Biology of Cancer and AIDS Exam 1B_Key Instructor...

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