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SCAN0092 - Intrinsic Pathway mince Extrinsic Pathway VII i...

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Unformatted text preview: Intrinsic Pathway mince Extrinsic Pathway VII i VIIa‘VT'F vamnm Iihuy Fibrlnogen —. Fibrin monomer xnia Fibrin polymer copyright 1996 M_w.ng Cross-urn lbrln -ol CLOTTING FACTORS AND HELATED COAGULATION TESTS Imumsic swarm . VWQP "1 {Hafiz yA: xn ' Eflkmiic 5mm than Fami- Factors Limiting Clot Growth or Formation . Two homeostatic mechanisms prevent clots from becoming large I Swift removal of clotting factors I Inhibition of activated clotting factors 6/2/2010 Coagulation Phase 3: Common Pathways to the Fibrin Mesh I Thrombin catalyzes the polymerization of fibrinogen into fibrin I Insoluble fibrin strands form the structural basis of a 0101’ I Fibrin causes plasma to become a gel-like trap I Fibrin in the presence of calcium ions activates factor XIII that: I Cross-links fibrin . Strengthens and stabilizes the clot new“ a 2m mu. MW e. a“. mm a i'lowjmm cam-m Clot Retraction and Repair I Clot retraction 7 stabilization of the clot by squeezing serum from the fibrin strands I Repair I Platelet-derived growth factor (PDGF) stimulates rebuilding of blood vessel wall I Fibroblasts form a connective tissue patch b‘d rill; , I Stimulated by vascular endothelial growth factor (VEGF), endothelial cells multiply and restore the endothelial lining «we; saw fur—my m: m. “hm-x . inhibition of Clotting Factors Fibrin acts as an anticoagulant by binding thrombin and preventing its: - Positive feedback effects of coagulation I Ability to speed up the production of prothrombin activator via factor V I Acceleration of the intrinsic pathway by activating platelets Thrombin not absorbed to fibrin is inactivated by antithrombin III Heparin, another anticoagulant, also inhibits thrombin activity am.» a :van mm ant—mt m mum, a M man man, P5361 in 12 ...
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