CE Thombosis 10-10

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Unformatted text preview: s αIIBβ3 GP Ib/IX/V Bound platelets GPIa Activated αIIBβ3 1. Unbound platelets Fibrinogen VWF Binding Fibrinogen at low shear vWF at high shear GPIb to vWF A1 domain occurs without activation at very high shear (Ruggeri 2006) Goals: Recreate arterial thrombosis Pathologic hemodynamics Quantify growth with high resolution Show to occlusion (1 billion platelets) Occlusion in <30 min CFD: Shear rate is 100x normal '"#### '##### /6,$1&7$),&389(5 #)& #)+ #)% #)* #)$ #)( #)" #)' "" "$ "% ! " #$%&'#()$*+,&! %-*.&/),*-(#(&/012$+,&3445 "& (# (" # 7$:#0(&-2&;$<#%%$1=&3445 &#### %#### $#### "#### # !"#### "# Bark Ku 2010 ) s / 1 450,000 ( e t 400,000 a R r 350,000 a e h 300,000 S Shear rises with thrombosis 250,000 75 80 85 % Stenosis 90 95 100 Bark Ku 2010 Shear up 50% with roughness S he a r R a te ( 1 / s ) 0.4 10 000 200 00 1 000 00 35 000 0 4 5,000 0.2 6 ,800 3 0 1 ,0 0 0 51 ,000 5 36,0 0 0 r/ r0 0 -0.2 -0.4 - 0 .4 - 0.2 x/ r0 0 0 .2 0 .4 Bark Ku 2010 In vitro experiment In Tubular stenosis with high shear at throat Collagen coating Optical visualization – clear tubes Optical (Ku Biorheol 06) Whole Blood Whole RBCs+platelets+vWF+Ca++ RBCs juggle the platelets to the walls Single pass eliminates positive feedback from activation Reproducible Thrombosis Movie of occlusion Movie Histology and µCT Thrombus Volume Thrombus Grows in 2 Phases Growth rate is shear dependent Thrombus at throat Thrombus Velocity >2 m/s Transit time <10 microsec Results • Thrombus occurs in the throat of the stenosis, not recirc region Rapid...
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This note was uploaded on 02/08/2011 for the course ME 3141 taught by Professor Staff during the Fall '10 term at Georgia Institute of Technology.

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