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05-ReceptorsS11b

05-ReceptorsS11b - Cell receptors Lecture 05/Chapter 9 Cell...

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Cell receptors Lecture 05/Chapter 9
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2 Cell communication Communication between cells requires: Ligand : Receptor protein : Ligand-receptor binding conveys information Initiates a response through signal transduction
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Cell communication 3
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4 Signal transduction Signal transduction : Transmitting & relaying the signal Different cell types can respond differently to the same signal
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5 Cellular responses Growth, maturation, gene expression, metabolism, death Control of gene expression Cells can also respond by activating or inactivating proteins Modification of proteins: cleavage, methylation, phosphorylation, etc.
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Phosporylation Some kinases are cytoplasmic, some double as membrane receptors 6 Figure 9.3
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Receptor types Receptors can be defined by their location 1. Located within the cell 2. Have intracellular & extracellular domains Bind a ligand outside the cell 7
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8 Nuclear receptors Action is direct:
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