{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

Lecture 3 - BCMB 3100 Lecture 3 Horton Chapter 3 Know the...

Info iconThis preview shows pages 1–6. Sign up to view the full content.

View Full Document Right Arrow Icon
(Problems: 4,6,8,9,10,15) Know the structure, names and classes of the 20 common amino acids Know pKa’s of α -amino and carboxyl groups, and any ionizable side groups Know potential H-bonding and ‘salt-bridging’ interactions Titration curve of amino acids BCMB 3100 - Lecture 3 Horton Chapter 3 Overview Diversity of protein function Definition of amino acids Memorize complete structure of 20 common amino acids!!! pKa’s of α amino and α carboxyl groups Amino acids with ionizable side groups Titration curve
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Examples of Protein Function Enzymatic catalysis: – enzymes increase reaction rates by 10 6 -fold; – nearly all known enzymes are proteins – dictates chemistry and metabolism Transport & storage: – small molecules and ions are transported by proteins - examples: hemoglobin, myoglobin Coordinated motion: – examples: myosin and actin (muscle movement) Examples of Protein Function Mechanical support: – collagen (tensile strength to skin and bones) Immune protection: – antibodies Generation & transmission of nerve impulses: – acetylcholine receptor Control of growth and differentiation: – DNA binding proteins (repressors, activators, transcription factors, hormones, regulation of translation)
Background image of page 2
Catalysts: enzymes increase reaction rates Urease urea Rate enhancement of 10 15 Test tube - 2,642 yrs/molecule Vs Cell - 37 μ sec/molecule James Sumner Nobel Prize 1946 Protein Function - Catalysis Showed enzymes are proteins Δ G ~ 25 kcal mol -1 or 104.5 kJ mol -1 M any small molecules and ions are transported by proteins. Examples: hemoglobin, transferrin, pores. Fig. 4.49, Horton Transferrin Hemoglobin Protein Function - Transport Fig .49
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Motion: Combination of enzymes with structural proteins. Examples: flagella, or muscle (myosin and actin). Protein Function – Coordinated Motion Fig1.14 Structural proteins shapes the cells (tubulin and actin) and gives tensile strength to skin (collagen). Protein Function – Mechanical Support collagen triple helix Tubulin - GFP actin
Background image of page 4
Control of cell information such as g ene expression and mRNA translation (eg. repressors and activators). Protein Function – Gene Expression Fig 21.14 Cytokines, hormones, receptors Examples: Insulin, leptin, HGH.
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Image of page 6
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}