Lecture 3 - (Problems: 4,6,8,9,10,15) Know the structure,...

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Unformatted text preview: (Problems: 4,6,8,9,10,15) Know the structure, names and classes of the 20 common amino acids Know pKas of -amino and carboxyl groups, and any ionizable side groups Know potential H-bonding and salt-bridging interactions Titration curve of amino acids BCMB 3100 - Lecture 3 Horton Chapter 3 Overview Diversity of protein function Definition of amino acids Memorize complete structure of 20 common amino acids!!! pKas of amino and carboxyl groups Amino acids with ionizable side groups Titration curve Examples of Protein Function Enzymatic catalysis: enzymes increase reaction rates by 10 6-fold; nearly all known enzymes are proteins dictates chemistry and metabolism Transport & storage: small molecules and ions are transported by proteins - examples: hemoglobin, myoglobin Coordinated motion: examples: myosin and actin (muscle movement) Examples of Protein Function Mechanical support: collagen (tensile strength to skin and bones) Immune protection: antibodies Generation & transmission of nerve impulses: acetylcholine receptor Control of growth and differentiation: DNA binding proteins (repressors, activators, transcription factors, hormones, regulation of translation) Catalysts: enzymes increase reaction rates Urease urea Rate enhancement of 10 15 Test tube - 2,642 yrs/molecule Vs Cell - 37 sec/molecule James Sumner Nobel Prize 1946 Protein Function - Catalysis Showed enzymes are proteins G ~ 25 kcal mol-1 or 104.5 kJ mol-1 M any small molecules and ions are transported by proteins. Examples: hemoglobin, transferrin, pores. Fig. 4.49, Horton Transferrin Hemoglobin Protein Function - Transport Fig .49 Motion: Combination of enzymes with structural proteins. Examples: flagella, or muscle (myosin and actin). Protein Function Coordinated Motion Fig1.14 Structural proteins shapes the cells (tubulin and actin) and gives tensile strength to skin (collagen). Protein Function Mechanical Support collagen triple helix Tubulin - GFP actin Motion: Combination of enzymes with structural proteins. Examples: flagella, or muscle (myosin and actin). Protein Function Coordinated Motion Fig1.14 Structural proteins shapes the cells (tubulin and actin) and gives tensile strength to skin (collagen)....
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This note was uploaded on 02/07/2011 for the course BCMD 3100 taught by Professor Rose during the Spring '11 term at University of Georgia Athens.

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Lecture 3 - (Problems: 4,6,8,9,10,15) Know the structure,...

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