Lecture 5 - BCMB 3100 Announcement The study guides I have...

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Unformatted text preview: BCMB 3100 Announcement The study guides I have uploaded to the E-Learning Commons are a good indication about what will be covered on the test. We will review chapters 1- 4 at the breakout session on Monday and in class on the Feb. 4. Test 1 Monday Feb. 2 BCMB 3100 Lecture 5 Horton Chapter 4 Proteins: 3D structure & Function Part 1 Conformation- three dimensional shape Native conformation- each protein folds into a single stable shape necessary for proper biological function. Several diseases are due to protein mis-folding. Same sequence but different fold Alzheimer's Disease Prions (Mad Cow) Dr. Al Jenny Stanley B. Prusiner Nobel Prize 1997 for work on Prions. Proteins: 3D structure & Function Presence of microscopic holes Blood, Sweat, Tears Actually visualize the electron density! X-Ray diffraction NMR Energy Transfers NMR determination of protein structure Pros Cons 1 - No Crystals 1 - limited in data 2 - Can do Dynamics 2 - protein size limits 3 - Can detect protons 3 resonance assignments Nuclear magnetic resonance spectroscopy (NMR) 1 H, 13 C, 15 N Four Principles of the Protein Folding Problem 1) Bury Hydrophobic Groups 2) Expose Polar Groups or Satisfy Hydrogen Bonding....
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This note was uploaded on 02/07/2011 for the course BCMD 3100 taught by Professor Rose during the Spring '11 term at University of Georgia Athens.

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Lecture 5 - BCMB 3100 Announcement The study guides I have...

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