RelativeResourceManager

RelativeResourceManager - Gametic Disequilibrium II Sex and...

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1 Gametic Disequilibrium II Sex and Recombination Segregation and Recombination ± Independent assortment (segregation). ² Loci on separate chromosomes. ± Crossing over. ² Leads to recombination of alleles at loci on the same chromosome. ± Linkage. ² Alleles at loci on the same chromosome may tend to be inherited together. ± Physical distance. ± Recombination “hot spots.” Gametic Disequilibrium (text refers to this as ‘linkage disequilibrium’) ± Definition: Non-random association among alleles at separate loci ² Observed frequencies of alleles occurring together differs from the random expectation. ² Alleles at linked loci are more likely to be in disequilibrium, but linkage is not necessary for disequilibrium to be maintained. ² Alleles at unlinked loci may be in disequilibrium because of ± Selection ± Genetic drift ± Admixture (gene flow between species) ² Recombination will eventually break-up associated alleles. ± The expected level of gametic disequilibrium is always zero.
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2 Recombination in Double Heterozygotes Changes Disequilibrium ± May be in coupling or repulsion phase. ± One recombination event changes phase for just two chromosomes. A B A B a b a b Recombination A b A B a b a B a B a b A b A B a B a B A b A b A B a b A b a B A B A B a b a b Other two-locus Genotypes Changes Gametic Disequilibrium Coupling Repulsion Gametic Disequilibrium D p p g D p p g D p p g D p p g b a B a b A B A + = =
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RelativeResourceManager - Gametic Disequilibrium II Sex and...

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