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Unformatted text preview: PSYC 015 Biological Psychology (Fall 2010) Exam 2 Study Guide Psychopharmacology (Chapter 4 pages 103 to 114; Chapter 18)- What are the various (11 in total) ways a drug can interact with synaptic transmission? 1. Drug serves as NT precursor 2. Drug inhibits NT synthesis 3. Drug prevents storages of NT in vescicles 4. Drug stimulates release of NT 5. Drug inhibits release of NT 6. Drug stimulates postsynaptic receptors 7. Drug blocks postsynaptic receptors 8. Drug stimulates autoreceptors; inhibits release of NT 9. Drug blocks autoreceptors; increases release of NT 10. Drug inhibits NT degradation 11. Drug blocks reuptake- What is the difference between pharmacokinetics and pharmacodynamics? Pharmacokinetics: the factors contributing to the movement of a drug through the body Pharmacodynamics: the study of physiological and biochemical interactions of a drug with the target tissue responsible for the drugs effects o How a drug interacts with your body- What are the 5 aspects of pharmacokinetics? 1. Administration a. Routes i. Oral slowest ii. Subcutaneous (SC) injection iii. Intramuscular (IM) injection iv. Intraperitoneal (IP) injection into stomach (mostly animals), fast 45 sec. v. Intravenous (IV) injection vi. Intracerebroventricular (ICV) injection directly to brain (actually fastest) vii. Inhalation FASTEST 2. Absorption 3. Distribution a. Goes where there is vascularizaiton i. Brain ii. Liver iii. Kidney iv. Fetus v. Muscle vi. Fat (not highly vascularized) 4. Metabolism a. How the body breaks down the drug i. Enzymes in gut and blood metabolize b. How fast metabolism occurs determines how long the drugs effects are felt c. Liver and kidneys play huge role in metabolism and excretion (respectively) 5. Excretion a. Elimination of drug b. Renal excretion urine c. Fecal excretion d. Respiration lungs e. Perspiration sweat- What system do drugs take advantage of to distribute throughout your body? Circulatory system: all tissues in the body need the nutrients from blood to survive o Oxygen, glucose, protein- What is the fastest route of drug administration when talking about drug abuse and why?- Fastest route with the exception of ICV (intracerebroventricular) which is directly into the brain Inhalation absorbed into capillaries in the lungs- With the oral route of administration, where does most of the absorption occur? Most 80% (of the drug that gets into the blood) is absorbed through the small intestines, other 20% is absorbed through the stomach- What are the roadblocks to absorption? (particularly associated with the oral route) Acidic environment of the stomach Drugs must cross the tissue lining, walls of blood vessels to enter blood stream may have limited capacity to cross these barriers o Hydrophobic (Lipophylic) able to readily absorb and distribute through lipid barriers o Hydrophilic (Lipophobic) not able to readily absorb and distribute through lipid barriers...
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- Spring '11
- Biological Psychology